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Protein Kinase A (PKA) Activation: Elevated cAMP levels activate PKA

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Castelli, M., Friedman, K., Sherry, J., Brazzillo, K., Genoble, L., Bhargava, P

In further embodiments, administration may occur in vivo

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Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased